Like Adderall or methamphetamine , Vyvanse works by increasing activity in the central nervous system CNS. This action can make the individual feel more alert, attentive, and energetic. How long the effects of Vyvanse persist largely depends on the size of the dose that is used. Vyvanse, as a prodrug, must be broken down by the body before it will start to work. Once metabolized, the effects can last up to 12 hours.
The half-life of Vyvanse is based on the active ingredient lisdexamfetamine, which, as noted, has a half-life of less than an hour. It is eventually converted to dextroamphetamine, which has a much longer half-life of around 12 hours. Vyvanse can be administered in several different doses: 10 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg, or 70 mg. How long Vyvanse can be identified on a drug screen depends on the method of testing.
Conventional drug testing methods include urine, saliva, blood, and hair follicle screenings. Urine — Vyvanse can be found in a urine test for up to three days after the last use. Saliva — Saliva tests are often used because drug levels are usually similar or higher than those detected in blood, and they are much less invasive. Vyvanse will test positive on a saliva drug screen for up to 48 hours after the last use. Blood — How long Vyvanse can be identified in the blood depends greatly on its half-life, which is relatively short.
Vyvanse will only be detectable on a blood test for about 8 hours following use. Hair — A hair follicle test is sometimes used to detect the presence of drugs for much longer than which other methods are capable. For example, Vyvanse use can be revealed on a hair drug test for up to 90 days after the last use.
Frequency and amount of use — How long Vyvanse stays in the system depends on the amount and frequency at which it is taken. User health and activity levels — In general, drugs are metabolized faster in people who are healthier and more active. As has been already mentioned, it is converted into D-amphetamine after absorption from the gastrointestinal tract. And with the said drug having a significantly longer half-life of about 12 hours , it will stay in the system for around 60 hours following the last dose.
Lisdexamfetamine dimesylate may not always show up on a urine test. If the test is for amphetamines, it can be detected. Results are instant, allowing the tester to get their answers quickly. Blood testing for amphetamines is highly accurate.
However, it is more difficult and more expensive than urine testing. It is also less likely to catch the presence of a drug, including Vyvanse, if it is not being used frequently. With regards to how long Lisdexamfetamine dimesylate stays in the blood, its active ingredient, d-amphetamine, remains detectable for 3. This range is according to a study of pediatric patients aged years who were given a single oral dose of 30, 50, or 70mg of Vyvanse. Hair testing for Lisdexamfetamine dimesylate, as well as other drugs, is expensive to complete, and as such is rare.
However, it is where there is the greatest risk for a positive result. When talking about the majority of the body, it is mere hours or days, but when it comes to the hair, Vyvanse and other amphetamines can remain present and detectable for as long as three months. Saliva testing is quite rare.
Because these tests do not differentiate between amphetamine and racemic compounds such as Dextroamphetamine, the drug Lisdexamfetamine dimesylate is converted into, Vyvanse will almost certainly show up on a drug test as an amphetamine.
Usually, they are looking for ways to make Vyvanse wear off faster. However, not all variables that affect how long Vyvanse lasts in the system can be altered. While the half-life of Vyvanse has been determined through clinical tests, it is an average of all of those who were part of the trials.
Some people eliminate the drug faster than others and vice versa. Factors that affect how long Vyvanse stays in the system include:. The factors discussed above are only but a part of a long list of factors that may affect how long drugs such as Lisdexamfetamine dimesylate will stay in the system.
There are no specific methods guaranteed to get Lisdexamfetamine dimesylate out of the system faster than it naturally does, but there are methods that are used for flushing out drugs in general that can help.
These include:. While looking for alternatives to Vyvanse is a good idea, the best course of action for those suffering from addiction or abuse is to discontinue use safely and let the body do the work — give it time to metabolize and eliminate it naturally. Drug rehabilitation centers can help those who abuse or are addicted to Lisdexamfetamine dimesylate or any other substance get clean and live a better life. There are many addiction treatment programs that can help those suffering from addiction to start their journey to recovery and most importantly, stay clean.
Isaak Stotts is an in-house medical writer in AddictionResource. After graduation, he became a substance abuse counselor, providing individual, group, and family counseling for those who strive to achieve and maintain sobriety and recovery goals. He has a particular interest in psychopharmacology, nutritional psychiatry, and alternative treatment options involving particular vitamins, dietary supplements, and administering auricular acupuncture. AddictionResource aims to present the most accurate, trustworthy, and up-to-date medical content to our readers.
Our team does their best for our readers to help them stay informed about vital healthcare decisions. Our writers and reviewers are experienced professionals in medicine, addiction treatment, and healthcare. AddictionResource fact-checks all the information before publishing and uses only credible and trusted sources when citing any medical data. The Verified badge on our articles is a trusted sign of the most comprehensive scientifically-based medical content. If you have any concern that our content is inaccurate or it should be updated, please let our team know at [email protected].
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